{"id":153183,"date":"2024-10-31T09:00:31","date_gmt":"2024-10-31T09:00:31","guid":{"rendered":"https:\/\/beta-ukri.msappproxy.net\/?p=153183"},"modified":"2024-11-14T10:18:01","modified_gmt":"2024-11-14T10:18:01","slug":"introducing-a-refreshed-roadmap-for-health-related-research","status":"publish","type":"post","link":"https:\/\/www.ukri.org\/blog\/introducing-a-refreshed-roadmap-for-health-related-research\/","title":{"rendered":"Introducing a refreshed roadmap for health-related research"},"content":{"rendered":"<p>I\u2019m pleased to say that the Biotechnology and Biological Sciences Research Council\u2019s (BBSRC) refreshed <a href=\"\/publications\/BBSRC-integrated-understanding-of-health-strategic-framework\/\">Bioscience for an Integrated Understanding of Health (BIUH) Strategic Research and Innovation Framework<\/a> is live.<\/p>\n<p>I know that\u2019s a lot of words, but I\u2019ll try to explain why I think they really mean something.<\/p>\n<p>But before I do, allow me to acknowledge the swathe of individuals from across BBSRC\u2019s advisory community whose collective thoughts are reflected in our updated framework.<\/p>\n<p>I\u2019m deeply grateful to everyone involved, but I want to say a particular thank you to Professors Louise Dye and Paul Haggarty. As former chairs of BBSRC\u2019s <a href=\"\/who-we-are\/bbsrc\/board-and-panel-membership\/strategy-advisory-panels\/bioscience-for-an-integrated-understanding-of-health\/\">Bioscience for Health Strategy Advisory Panel,<\/a> both Louise and Paul were extremely generous with their time in helping shape our future thinking.<\/p>\n<p>Clearly, it\u2019s taken a lot of time and effort to produce such a document. So why have we done it?<\/p>\n<h2>BBSRC\u2019s multiple roles in health research<\/h2>\n<p>\u2018Health\u2019 sits in a somewhat unique place within BBSRC\u2019s portfolio. As far as human health is concerned, this is the only area of bioscience research and innovation where BBSRC is not the primary national public funder. In fact, there are many other funders spanning across the public, private and third sector.<\/p>\n<p>This means our role as a funder sits in a particularly complex landscape, so it\u2019s really important to be clear about why we prioritise the research interests that we do.<\/p>\n<p>And first and foremost, let me say that the research and innovation BBSRC supports in this space has tremendously unique value.<\/p>\n<p>That unique value is not only in creating impactful knowledge, but in developing the tools needed to support the quest for healthier, happier lives.<\/p>\n<p>Our refreshed framework sets out what we think this unique value is. Hopefully the framework also clearly sets out how that value complements the remit of other health funding organisations that researchers may engage with to support their work.<\/p>\n<h2>What makes a resilient organism and how can this go wrong?<\/h2>\n<p>BBSRC-funded research plays a pivotal role in developing our understanding of what makes humans, and indeed all living things, healthy.<\/p>\n<p>We are ultimately curious to understand the deep biological mechanisms at play in keeping us robust and resilient to challenge, which is a good definition of \u2018health\u2019.<\/p>\n<p>When these processes start to break down, it leaves us frail and susceptible to a range of infectious and non-infectious diseases, particularly as we age. Understanding how this shift happens means we can develop strategies to better avoid this, or at the very least delay it!<\/p>\n<h2>But it\u2019s not just about us humans<\/h2>\n<div id=\"attachment_153193\" style=\"width: 310px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-153193\" class=\"size-medium wp-image-153193\" src=\"\/wp-content\/uploads\/2024\/10\/BBSRC-301024-JIC-Purple-tomatoes-300x200.jpg\" alt=\"Purple tomato fruit genetically engineered to produce anthocyanins. Credit: John Innes Centre\" width=\"300\" height=\"200\" srcset=\"https:\/\/www.ukri.org\/wp-content\/uploads\/2024\/10\/BBSRC-301024-JIC-Purple-tomatoes-300x200.jpg 300w, https:\/\/www.ukri.org\/wp-content\/uploads\/2024\/10\/BBSRC-301024-JIC-Purple-tomatoes-735x490.jpg 735w, https:\/\/www.ukri.org\/wp-content\/uploads\/2024\/10\/BBSRC-301024-JIC-Purple-tomatoes-750x500.jpg 750w, https:\/\/www.ukri.org\/wp-content\/uploads\/2024\/10\/BBSRC-301024-JIC-Purple-tomatoes-510x340.jpg 510w, https:\/\/www.ukri.org\/wp-content\/uploads\/2024\/10\/BBSRC-301024-JIC-Purple-tomatoes-360x240.jpg 360w, https:\/\/www.ukri.org\/wp-content\/uploads\/2024\/10\/BBSRC-301024-JIC-Purple-tomatoes.jpg 1500w\" sizes=\"auto, 300px\" \/><p id=\"caption-attachment-153193\" class=\"wp-caption-text\">Purple tomato fruit genetically engineered to produce anthocyanins. Credit: John Innes Centre<\/p><\/div>\n<p>BBSRC\u2019s research remit, of all the funders in the health landscape, is also unique because it has a major focus on food and agriculture. That being the production of the food we eat and the rapidly changing systems needed to deliver it.<\/p>\n<p>For BBSRC, that means we must help investigate:<\/p>\n<ul>\n<li>the processing of food<\/li>\n<li>what happens to our bodies when we eat food<\/li>\n<li>the huge populations of microbes we share our bodies with when we eat<\/li>\n<li>how our bodies change depending on what we eat, or even when we eat<\/li>\n<\/ul>\n<p>We know that dietary influences on health are enormous. That\u2019s why a joined-up research approach is key to understanding what changes can be made to promote better health outcomes and the innovations that will support this.<\/p>\n<h2>The UK\u2019s major public funder of animal health research<\/h2>\n<p>While BBSRC may not be the primary UK funder of human health research, we definitely are when it comes to animal health research. Our investments are primarily focused on tackling emerging and endemic diseases of farmed animals.<\/p>\n<p>Major BBSRC-supported national centres, such as the <a href=\"https:\/\/www.pirbright.ac.uk\/\">Pirbright Institute<\/a> and <a href=\"https:\/\/vet.ed.ac.uk\/roslin\">Roslin Institute<\/a>, are global leaders in infectious disease research. Their research aims to alleviate the suffering of animals and the people who depend on them, meaning they also play a crucial role in protecting national and global food security.<\/p>\n<h2>Harnessing the power of comparative biology<\/h2>\n<p>BBSRC\u2019s unique funding role, as it spans human and animal health and disease, means we add a lot of research value by sharing and comparing. For example, many animals have quite different ageing trajectories, which is why you\u2019ll rarely see an old-looking wild bird!<\/p>\n<p>We can learn an awful lot through comparative biology approaches that seek to understand both the similarities and differences between animals, including humans.<\/p>\n<h2>The One Health approach<\/h2>\n<p>Our dual role in health research has enabled us to be early pioneers of <a href=\"https:\/\/www.who.int\/news-room\/questions-and-answers\/item\/one-health\">One Health<\/a> approaches to disease research. This approach recognises that pathogens affecting humans typically originate from the wider environment, evolving and transmitting through the food system.<\/p>\n<p>Effective strategies for predicting, preventing and mitigating infectious disease outbreaks require a comprehensive understanding of the entire system in which they emerge, evolve and spread. In turn, this understanding helps us better predict which measures will be most effective at preventing and curtailing outbreaks of new or re-emerging pathogens.<\/p>\n<p>In cases like the slow-moving pandemic of antimicrobial resistance (AMR), One Health aids our understanding of the factors driving the emergence and spread of microbes resistant to our chemical control toolkit, guiding us towards new and more effective strategies to counteract this.<\/p>\n<p>Take COVID-19 as an example. Our collective response to the challenges posed by COVID-19 highlighted the value of our work across human and animal infectious disease systems. Adopting a One Health approach, researchers can integrate knowledge and tools to develop critical interventions, such as new vaccines for major epidemics, at increased speed and scale.<\/p>\n<h2>Driving novel innovations<\/h2>\n<div id=\"attachment_153192\" style=\"width: 310px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-153192\" class=\"size-medium wp-image-153192\" src=\"\/wp-content\/uploads\/2024\/10\/BBSRC-301024-African-Buffalo-300x200.jpg\" alt=\"A group of African Buffalo standing in long grass.\" width=\"300\" height=\"200\" srcset=\"https:\/\/www.ukri.org\/wp-content\/uploads\/2024\/10\/BBSRC-301024-African-Buffalo-300x200.jpg 300w, https:\/\/www.ukri.org\/wp-content\/uploads\/2024\/10\/BBSRC-301024-African-Buffalo-735x490.jpg 735w, https:\/\/www.ukri.org\/wp-content\/uploads\/2024\/10\/BBSRC-301024-African-Buffalo-750x500.jpg 750w, https:\/\/www.ukri.org\/wp-content\/uploads\/2024\/10\/BBSRC-301024-African-Buffalo-510x340.jpg 510w, https:\/\/www.ukri.org\/wp-content\/uploads\/2024\/10\/BBSRC-301024-African-Buffalo-360x240.jpg 360w, https:\/\/www.ukri.org\/wp-content\/uploads\/2024\/10\/BBSRC-301024-African-Buffalo.jpg 1500w\" sizes=\"auto, 300px\" \/><p id=\"caption-attachment-153192\" class=\"wp-caption-text\">African Buffalo. Credit: The Pirbright Institute<\/p><\/div>\n<p>BBSRC\u2019s investments in health research mean we can drive novel biotechnology innovations, which are critical in equipping us with the tools and technologies needed to detect and tackle infectious disease.<\/p>\n<p>We see an integrated understanding of health, and BBSRC\u2019s role supporting this, as essential in developing real-world solutions that improve health and wellbeing for humans and animals alike. The nomenclature is a mouthful, but we use it now for a reason!<\/p>\n<h2>Why refresh our roadmap for health research?<\/h2>\n<p>We published BBSRC\u2019s first Bioscience For Health Strategic Research Framework in 2015, and much has changed since then. Thinking has evolved and so have the ways in which we work.<\/p>\n<p>With the formation of UK Research and Innovation (UKRI), the research councils have gained access to more collective funding mechanisms to support more systemic, interdisciplinary approaches.<\/p>\n<p>This includes support from UKRI\u2019s strategic themes, the likes of which include <a href=\"\/who-we-are\/our-vision-and-strategy\/ukri-strategic-themes\/securing-better-health-ageing-and-wellbeing\/\">securing better health, ageing and wellbeing<\/a> and <a href=\"\/who-we-are\/our-vision-and-strategy\/ukri-strategic-themes\/tackling-infections\/\">tackling infections<\/a>, the latter of which I take a lead for on behalf of UKRI partners.<\/p>\n<h2>Global challenges, global solutions<\/h2>\n<p>Mechanisms such as the <a href=\"\/what-we-do\/browse-our-areas-of-investment-and-support\/global-challenges-research-fund\/\">global challenges research fund<\/a> have also enabled us to take a more multilateral approach to health problems. This work is essential as many of the challenges impact the global south and countries undergoing rapid social, economic and demographic change in particular.<\/p>\n<p>Exciting new national capabilities have also been established since publishing our last framework, namely the <a href=\"https:\/\/quadram.ac.uk\/\">Quadram Institute<\/a>. As one of BBSRC\u2019s <a href=\"\/who-we-are\/bbsrc\/who-we-are\/strategically-supported-institutes\/\">strategically supported institutes<\/a>, Quadram Institute is on a mission to deliver healthier lives through innovation in gut health, microbiology and food.<\/p>\n<p>COVID-19 and other major diseases such as avian influenza have emerged and are still with us. As they evolve they are posing new challenges, as the recent detection of avian influenza in cows in the US has shown.<\/p>\n<p>We\u2019ve learned a lot and worked increasingly in strategic partnership with other funders, nationally and internationally, to respond to health challenges as they emerge.<\/p>\n<h2>Looking backwards and forwards<\/h2>\n<p>Our new framework showcases some of the exciting impacts and outcomes BBSRC-supported researchers have achieved since the original framework was published. It also provides a more nuanced and contemporary framing for BBSRC\u2019s ongoing health research mission.<\/p>\n<p>We are building on our original themes and priority areas as well as setting out what we seek to achieve in coming years, working with our research communities and other partners.<\/p>\n<h2>Bioscience is an evolving landscape<\/h2>\n<p>As the world of bioscience evolves, so must our research strategy. We are currently consulting on a review of BBSRC\u2019s <a href=\"\/news\/new-bbsrc-chief-launches-major-bioscience-consultation\/\">Forward Look for UK Bioscience<\/a> and as we update these strategies, we expect to frame and use them in complementary ways.<\/p>\n<p>We will also soon be publishing a collection of deep dive position papers on AMR and ageing research. These are two areas of collaborative strategic endeavour where we think a further unpacking of what BBSRC-funded bioscience can achieve will be helpful and timely to us and our partners.<\/p>\n<p>I hope our refreshed framework will interest and even inspire you, our wider research community and our collaborative industry partners.<\/p>\n<p>We welcome your feedback and look forward to working with you to deliver exciting new health research outcomes that will make a real difference to us all.<\/p>\n<h2>Interested in learning more about BBSRC\u2019s role in driving the One Health approach?<\/h2>\n<p><a href=\"https:\/\/public.govdelivery.com\/accounts\/UKRI\/subscriber\/new\">Sign up to our alerts to get notified about our next blog<\/a>, which takes a closer look at BBSRC&#8217;s One Health activity as we celebrate international One Health Day on Sunday 3 November.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>I\u2019m pleased to say that the Biotechnology and Biological Sciences Research Council\u2019s (BBSRC) refreshed Bioscience for an Integrated Understanding of Health (BIUH) Strategic Research and Innovation Framework is live. I know that\u2019s a lot of words, but I\u2019ll try to explain why I think they really mean something. But before I do, allow me to [&hellip;]<\/p>\n","protected":false},"author":83,"featured_media":153196,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[49],"tags":[],"wf_post_folders":[],"class_list":["post-153183","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bbsrc"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.ukri.org\/wp-json\/wp\/v2\/posts\/153183","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ukri.org\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ukri.org\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ukri.org\/wp-json\/wp\/v2\/users\/83"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ukri.org\/wp-json\/wp\/v2\/comments?post=153183"}],"version-history":[{"count":14,"href":"https:\/\/www.ukri.org\/wp-json\/wp\/v2\/posts\/153183\/revisions"}],"predecessor-version":[{"id":154262,"href":"https:\/\/www.ukri.org\/wp-json\/wp\/v2\/posts\/153183\/revisions\/154262"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ukri.org\/wp-json\/wp\/v2\/media\/153196"}],"wp:attachment":[{"href":"https:\/\/www.ukri.org\/wp-json\/wp\/v2\/media?parent=153183"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ukri.org\/wp-json\/wp\/v2\/categories?post=153183"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ukri.org\/wp-json\/wp\/v2\/tags?post=153183"},{"taxonomy":"wf_post_folders","embeddable":true,"href":"https:\/\/www.ukri.org\/wp-json\/wp\/v2\/wf_post_folders?post=153183"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}